李老師的主要研究領域為熱物性質的量測與關聯，尤其著重於相平衡的研究。台灣科技大學的熱物性研究室中已建立了多套用於密度、粘度、熱焓、反應動力，以及多種相平衡數據量測的裝置，其可操作的溫度與壓力範圍相當廣泛。有興趣量測的系統包括由水、有機物、離子熔液、電解質、超臨界流體、特用化學品、分散性染料、寡聚物或高分子等物質所組合而成的混合物。這些實驗的結果可做為推導新熱力學模式及開發新製程的基礎。近年來也從事以超臨界流體技術，製備奈米級與次微米級微粒的研究。該研究室的研究經費來源主要來自國科會，也有部份來自國內的產業界及研究機構。

1. Chang, S. C., M. J. Lee*, and H. M. Lin, 2008, “The Influence of Phase Behavior on the Morphology of Protein α-Chymotrypsin Prepared via a Supercritical Anti-Solvent Process,” J. Supercrit. Fluids, 44, 219-229.
2. Chiu, H. Y., R. F. Jung, M. J. Lee*, and H. M. Lin, 2008, “Vapor-Liquid Phase Equilibrium Behavior of Mixtures Containing Supercritical Carbon Dioxide near Critical Region,” J. Supercrit. Fluids, 44, 273-278.
3. Venkatesu, P., M. J. Lee*, and H. M. Lin, 2008, “Effect of Osmolyte or GdnHCl on Volumetric Properties of Aqueous Solutions Containing Cyclic Dipeptides,” Biochem. Eng. J., 38, 326-340.
4. Hung, S. B., I. K. Lai, H. P. Huang, M. J. Lee, and C. C. Yu*, 2008, “Reactive Distillation for Two-Stage Reaction Systems: Adipic Acid and Glutaric Acid Esterifications,” Ind. Eng. Chem. Res., 47, 3076-3087.
5. Hsieh, C. T., M. J. Lee*, and H. M. Lin, 2008, “Vapor-Liquid-Liquid Equilibria for Aqueous Systems with Methyl Acetate, Methyl Propionate, and Methanol,” Ind. Eng. Chem. Res., 47, 7927-7933.
6. Chang, S. C., M. J. Lee*, and H. M. Lin, 2008, “Preparation of Nano- and Micrometric Ceftazidime Particles with Supercritical Anti-Solvent Technique,” J. Phys. Chem. C, 112, 14835-14842.
7. Tsai,C. C., H. M. Lin, and M. J. Lee*, 2009, “Solubility of  1,5-Diaminobromo- 4,8-dihydroxyanthraquinone in Supercritical Carbon Dioxide with or without Cosolvent,” J. Chem. Eng. Data, 54, 1442-1446.
8. Lee, M. J.*, T. J. Ku, and H. M. Lin, 2009, “(Pressure-Volume-Temperature) Properties for Binary Oligomeric Solutions of Poly(Ethylene Glycol Mono-4-Octylphenyl Ether) with 1-Octanol or Acetophenone at Pressures up to 50 MPa,” J. Chem. Thermodyn., 41, 1178-1185.
9. Taha, M. and M. J. Lee*, 2010, “Buffer Interactions: Solubilities and Transfer Free Energies of TRIS, TAPS, TAPSO, and TABS from Water to Aqueous Ethanol Solutions,” Fluid Phase Equilibria, 289, 122-128.
10. Liao, W. C., H. M. Lin, and M. J. Lee*, 2010, “Excess Molar Enthalpies of Binary Systems of 2-Octanone or 3-Octanone with Dodecane, Tetradecane, or Hexadecane at 298.15 K,” J. Chem. Eng. Data, 55, 217-222.
11. Attri, P., P. Venkatesu*, and M. J. Lee, 2010, “Influence of Osmolytes and Denaturants on the Structure and Enzyme Activity of α-Chymotrypsin,” J. Phys. Chem. B, 114, 1471-1478.
12. Taha, M. and M. J. Lee*, 2010, ”Interactions of TRIS [tris(hydroxymethyl)- aminomethane] and Related Buffers with Peptide Backbone: Thermodynamic Characterization,” Physical Chemistry Chemical Physics, 12, 12840-12850. 
     
     
 
 

李教授曾於民國69-70年期間在國際操作分析顧問公司(台灣)擔任化學工程師，並於民國73年、82年，以及93年分別獲得中國化學工程學會所頒的最佳論文獎。

• 國際操作分析顧問公司,化學工程師,1981/06-1982/07.
• 國立台灣工業技術學院化工系,講師,1982/08-1989/01.
• 國立台灣工業技術學院化工系,副教授,1989/02-1993/07.
• 國立台灣科技大學化工系,教授,1993/08-迄今.
• 國立台灣科技大學化工系,系主任,2004/08-2007/07.