研究領域

1. 生物物理化學 (Biophysical chemistry)
2. 生物質譜學 (Biological mass spectrometry)
3. 生物光子學 (Biophotonics)
4. 奈米生物技術 (Nanobiotechnology)

目前研究計畫/方向

奈米生物技術，著重於高亮度螢光奈米鑽石的開發及其在生物醫學方面的應用

Development and use of surface-functionalized fluorescent nanodiamonds (FNDs) in biomedical sciences

著作選列/代表近作

1. T.-J. Wu, Y.-K. Tzeng, W.-W. Chang, C.-A. Cheng, Y. Kuo, C.-H. Chien, H.-C. Chang*, and J. Yu*, “Tracking the engraftment and regenerative capabilities of transplanted lung stem cells using fluorescent nanodiamonds,” Nature Nanotech. 8, 682–689 (2013).
2. Y.-K. Tzeng, O. Faklaris, B.-M. Chang, Y. Kuo, J.-H. Hsu, and H.-C. Chang*, “Superresolution imaging of albumin-conjugated fluorescent nanodiamonds in cells by stimulated emission depletion,” Angew. Chem. Int. Ed. 50, 2262–2265 (2011).
3. N. Mohan, C.-S. Chen, H.-H. Hsieh, Y.-C. Wu*, and H.-C. Chang*, “In vivo imaging and toxicity assessments of fluorescent nanodiamonds in Caenorhabditis elegans,” Nano Lett. 10, 3692–3699 (2010).
4. Y.-R. Chang, H.-Y. Lee, K. Chen, C.-C. Chang, D.-S. Tsai, C.-C. Fu, T.-S. Lim, Y.-K. Tzeng, C.-Y. Fang, C.-C. Han, H.-C. Chang*, and W. Fann*, “Mass production and dynamic imaging of fluorescent nanodiamonds,” Nature Nanotech. 3, 284–288 (2008).
5. C.-C. Fu, H.-Y. Lee, K. Chen, T.-S. Lim, H.-Y. Wu, P.-K. Lin, P.-K. Wei, P.-H. Tsao, H.-C. Chang*, and W. Fann*, “Characterization and application of single fluorescent nanodiamonds as cellular biomarkers,” Proc. Natl. Acad. Sci. USA 104, 727–732 (2007).

榮譽獲獎

中國化學會會誌103年度最佳論文獎

國科會卓越領航研究計畫

第52屆教育部學術獎

傑出人才基金會傑出人才講座

中央研究院深耕計畫

國科會傑出獎

中央研究院年輕學者著作獎